Gene Synthesis Market Overview
The Gene Synthesis Market Size is expected to reach USD 7.68 Billion by 2033. The Gene Synthesis industry size accounted for USD 2.03 Billion in 2023 and is expected to expand at a compound annual growth rate (CAGR) of 16.85% from 2023 to 2033. Gene synthesis is a laboratory technique that enables the artificial construction of DNA sequences, typically genes or genetic fragments, by chemically synthesizing nucleotides in a specific order to match a desired genetic code. This process allows researchers to design and create custom DNA sequences with precise control over the genetic information, enabling the creation of novel genes, modified versions of existing genes, or genetic constructs for various biotechnological applications, such as gene therapy, genetic engineering, and synthetic biology. Gene synthesis plays a crucial role in advancing our understanding of genetics and developing innovative solutions in fields like medicine, agriculture, and biotechnology.
Global Gene Synthesis Market Synopsis
COVID-19 Impact Analysis
The COVID-19 pandemic unexpectedly bolstered the Gene Synthesis market as it prompted a surge in demand for rapid research and development of diagnostics, treatments, and vaccines. With the need to study and manipulate the SARS-CoV-2 virus, as well as its variants, gene synthesis became an essential tool for scientists to design and create custom DNA sequences for various applications, including the production of viral proteins for vaccine development and the construction of diagnostic tools like PCR primers. This heightened demand not only underscored the crucial role of gene synthesis in responding to emerging infectious diseases but also drove innovations and investments in the field, ultimately expanding its market and potential for future applications beyond the pandemic.
Global Gene Synthesis Market Dynamics
The major factors that have impacted the growth of Gene Synthesis are as follows:
Drivers:
⮚     Biotechnology Advancements
The rapid advancement of biotechnology, particularly in areas such as gene editing (e.g., CRISPR-Cas9) and synthetic biology, is a major driver of the Gene Synthesis market. These innovations create a strong demand for custom DNA sequences, as researchers require precise and tailored genetic constructs for their experiments and applications.
Restraint:
- Regulatory Challenges
One significant restraint is the complex and evolving regulatory landscape surrounding gene synthesis, especially concerning the synthesis of potentially hazardous or controversial genetic material. Stringent regulations and ethical concerns can slow down the market’s growth by imposing compliance requirements and restricting certain types of research.
Opportunity:
⮚     Emerging Therapeutic Applications
The expanding scope of gene synthesis in therapeutic applications, such as gene therapy and vaccine development, presents a substantial opportunity. With increasing investments and breakthroughs in these areas, gene synthesis services are well-positioned to play a pivotal role in the development of novel treatments and vaccines, potentially driving significant market growth.
Gene Synthesis Market Segment Overview
By Method
Based on the Method, the market is segmented based on Solid-phase Synthesis, Chip-based Synthesis, and PCR-based Enzyme Synthesis. The Solid-phase Synthesis segment was projected to hold the largest market share in the Gene Synthesis market due to its efficiency, scalability, and ability to synthesize long DNA sequences, making it a preferred method for gene synthesis.
By Application
Based on the Application, the market has been divided into Gene & Cell Therapy Development, Vaccine Development, Disease Diagnosis, and Others. The Gene and cell Therapy Development segment is expected to hold the largest market share in the Gene Synthesis market due to the increasing demand for custom DNA constructs in the development of advanced therapies, including gene and cell therapies, which require precise genetic manipulation and synthesis.
By End-use
Based on End-use, the market has been divided into Biotechnology and Pharmaceutical Companies, Academic and Government Research Institutes, and Contract Research Organizations. The Biotechnology and Pharmaceutical Companies segment is expected to hold the largest market share in the Security market due to the industry’s critical data protection needs and substantial investments in cybersecurity to safeguard sensitive research, intellectual property, and patient information.
Global Gene Synthesis Market Regional Analysis
Based on region, the market has been divided into North America, Europe, Asia-Pacific, the Middle East & Africa, and Latin America. The area of North America is anticipated to dominate the market for the usage of Gene Synthesis, followed by those in Asia-Pacific and Europe.
North America Market
North America stands at the forefront of the Gene Synthesis market due to a combination of factors. The region boasts a robust biotechnology and pharmaceutical industry with a strong focus on research and development, making it a major driver of gene synthesis demand. Additionally, North America is home to numerous prominent academic and research institutions, fostering innovation and driving the need for custom DNA constructs. The availability of advanced biotechnology infrastructure, a skilled workforce, and substantial investments in emerging biotechnological fields like gene therapy and synthetic biology further solidify its leading position. Moreover, favorable regulatory frameworks and a supportive ecosystem for biotechnology startups and companies have contributed to North America’s dominance in the gene synthesis market, with a significant share of global gene synthesis service providers headquartered in the region.
Asia Pacific Market
The Asia-Pacific region is experiencing remarkable growth in the Gene Synthesis market, driven by several factors. Rapid industrialization, increased investments in biotechnology and life sciences research, and a growing emphasis on healthcare and pharmaceutical development in countries like China, India, Japan, and South Korea are driving the demand for custom DNA constructs. Moreover, the region benefits from a large pool of skilled scientists and researchers, making it an attractive hub for gene synthesis-related activities. Cost-effective labor and manufacturing capabilities have also led to competitive pricing for gene synthesis services, attracting global biotech companies to outsource their research and development efforts to Asia-Pacific service providers. Additionally, the region’s expanding healthcare infrastructure and rising awareness of personalized medicine are further fueling the adoption of gene synthesis technologies, making it a burgeoning player in the global gene synthesis market.
Competitive Landscape
The competitive landscape includes key players (tier 1, tier 2, and local) having a presence across the globe. Companies such as GenScript, Brooks Automation Inc. (GENEWIZ), Boster Biological Technology, Twist Bioscience, and ProteoGenix Inc. are some of the leading players in the global  Gene Synthesis Industry. These players have adopted partnership, acquisition, expansion, and new product development, among others as their key strategies.
Key Market Players:
- CrowdStrike Holdings Inc
- Check Point Software Technologies Ltd
- Cisco Systems Inc
- CyberArk Software Ltd
- Dell Technologies Inc
- Mandiant Inc
- Fortinet Inc
- IBM Corporation
- Imperva Inc
- Intel Security (Intel Corporation)
Key development:
In July of 2022, OraSure Technologies unveiled its OmniGene Gut DNA and RNA offering (OMR-205), catering to the needs of researchers focused on studying the gut microbiome.
In February 2022, Integrated DNA Technologies, Inc. introduced Alt-R HDR Donor Blocks, providing research professionals with a powerful tool to modify the genome through Homology-directed Repair (HDR) for the development of treatments.
Scope of the Report
Global Gene Synthesis Market, by Method
- Solid-phase Synthesis
- Chip-based Synthesis
- PCR-based Enzyme Synthesis
Global Gene Synthesis Market, by Application
- Gene & Cell Therapy Development
- Vaccine Development
- Disease Diagnosis
- Others
Global Gene Synthesis Market, by End-use
- Biotechnology & Pharmaceutical Companies
- Academic & Government Research Institutes
- Contract Research Organizations
Global Gene Synthesis Market, by Region
- North America
- US
- Canada
- Mexico
- Europe
- UK
- Germany
- France
- Italy
- Spain
- Benelux
- Nordic
- Rest of Europe
- Asia Pacific
- China
- Japan
- South Korea
- Indonesia
- Austalia
- Malaysia
- India
- Rest of Asia Pacific
- South America
- Brazil
- Argentina
- Rest of South America
- Middle East & Africa
- Saudi Arabia
- UAE
- Egypt
- South Africa
- Rest of Middle East & Africa
| Parameters | Indicators |
|---|---|
| Market Size | 2033: $7.68 Billion |
| CAGR | 16.85% CAGR (2023-2033) |
| Base year | 2022 |
| Forecast Period | 2023-2033 |
| Historical Data | 2021 |
| Report Coverage | Revenue Forecast, Competitive Landscape, Growth Factors, and Trends |
| Key Segmentations | Method, Application, End-use |
| Geographies Covered | North America, Europe, Asia-Pacific, Latin America, Middle East, Africa |
| Key Vendors | GenScript, Brooks Automation Inc. (GENEWIZ), Boster Biological Technology, Twist Bioscience, ProteoGenix Inc, Biomatik, ProMab Biotechnologies Inc, Thermo Fisher Scientific Inc, Integrated DNA Technologies Inc, OriGene Technologies Inc |
| Key Market Opportunities | • Expansion of gene synthesis in therapeutic applications, such as gene therapy and vaccine development. • Automation and high-throughput technologies enhance efficiency and affordability. |
| Key Market Drivers | • Advancements in biotechnology, including gene editing and synthetic biology. • Growing demand for personalized medicine and targeted therapies. • Increasing need for custom DNA constructs in research and development. |
REPORT CONTENT BRIEF:
- High-level analysis of the current and future Gene Synthesis Industry trends and opportunities
- Detailed analysis of current market drivers, restraining factors, and opportunities analysis in the future
- Historical market size for the year 2021, and forecast from 2023 to 2033
- Gene Synthesis market share analysis for each segment
- Competitor analysis with a comprehensive insight into its product segment, financial strength, and strategies adopted.
- Identifies key strategies adopted by the key players including new product development, mergers and acquisitions, joint ventures, collaborations, and partnerships.
- To identify and understand the various factors involved in the global Gene Synthesis market affected by the pandemic
- To provide year-on-year growth from 2022 to 2033
- To provide short-term, long-term, and overall CAGR comparison from 2022 to 2033.
- Provide Total Addressable Market (TAM) for the Global Gene Synthesis Market.
